How to prepare the infusion: put one tablespoon of the fruits, previously crushed , in boiling water and let steep for 10 minutes, drink 3-4 cups daily one hour before meals. Contraindications: with regard to side effects or undesirable effects, literature reports that it is generally a well-tolerated medicinal herb, but in more sensitive individuals it may give a mild laxative effect that ceases 2-3 days after the end of intake. Intake is not recommended in cases of allergy to Asteraceae. Avoid in cases of high blood pressure.Silymarin may increase estrogen elimination, so it should not be taken by women taking oral contraceptives or on replacement therapy (HRT).